Compare the pharmacokinetics of botanical adaptogens like ashwagandha versus St. John's wort for mitigating vasomotor menopausal symptoms.
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The searches the AI actually ran for this prompt.
SEED QUERY
Compare the pharmacokinetics of botanical adaptogens like ashwagandha versus St. John's wort for mitigating vasomotor menopausal symptoms.
3 real searches · 1 real-search pass
ashwagandha menopause vasomotor symptoms randomized trial pharmacokinetics withanolides review CYP interactionsGoogle ↗
OBSERVED
St John's wort menopausal hot flashes randomized trial pharmacokinetics hyperforin CYP3A4 P-glycoprotein induction reviewGoogle ↗
OBSERVED
NCCIH ashwagandha safety drug interactions St John's wort interactions menopause hot flashes evidenceGoogle ↗
OBSERVED
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Classifying 3 queries…
Searches and sources
ChatGPT3 real searches · gpt-6
ashwagandha menopause vasomotor symptoms randomized trial pharmacokinetics withanolides review CYP interactions Google ↗
St John's wort menopausal hot flashes randomized trial pharmacokinetics hyperforin CYP3A4 P-glycoprotein induction review Google ↗
NCCIH ashwagandha safety drug interactions St John's wort interactions menopause hot flashes evidence Google ↗
- Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study · pubmed.ncbi.nlm.nih.gov
- Effect of an ashwagandha (<fc><fi>Withania Somnifera</fi></fc>) root extract on climacteric symptoms in women during perimenopause: A randomized, <fc>double‐blind</fc>, placebo‐controlled study - Gopal - 2021 - Journal of Obstetrics and Gynaecology Research · obgyn.onlinelibrary.wiley.com
- A prospective, randomized, double-blind, placebo-controlled study on efficacy and safety of Ashwagandha root extract (Withania somnifera) for managing menopausal symptoms in women · pubmed.ncbi.nlm.nih.gov
- A prospective, randomized, double-blind, placebo-controlled study on efficacy and safety of Ashwagandha root extract (Withania somnifera) for managing menopausal symptoms in women · pmc.ncbi.nlm.nih.gov
- The effect of St John's wort extracts on CYP3A: a systematic review of prospective clinical trials · pubmed.ncbi.nlm.nih.gov
- The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose · pubmed.ncbi.nlm.nih.gov
- Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial · pubmed.ncbi.nlm.nih.gov
- Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study · pubmed.ncbi.nlm.nih.gov
- Ashwagandha: Usefulness and Safety · nccih.nih.gov
- Ashwagandha: Is it helpful for stress, anxiety, or sleep? · ods.od.nih.gov
- St. John’s Wort: Usefulness and Safety · nccih.nih.gov
- Drug interactions with St John's wort : mechanisms and clinical implications. · pubmed.ncbi.nlm.nih.gov
Queries
3 queries · click a column to sort
| Query / type | Search | Intent | Query class | Routing format | Cluster | Freq ↓ | Weight |
|---|---|---|---|---|---|---|---|
ashwagandha menopause vasomotor symptoms randomized trial pharmacokinetics withanolides review CYP interactions OBSERVED | Google ↗ AI Mode ↗ | — | — | — | — | 1x of 1 | |
St John's wort menopausal hot flashes randomized trial pharmacokinetics hyperforin CYP3A4 P-glycoprotein induction review OBSERVED | Google ↗ AI Mode ↗ | — | — | — | — | 1x of 1 | |
NCCIH ashwagandha safety drug interactions St John's wort interactions menopause hot flashes evidence OBSERVED | Google ↗ AI Mode ↗ | — | — | — | — | 1x of 1 |